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CG Dimono PTx — Dynamic Functional Dermal Filler
A revolutionary injectable dermal filler engineered to treat both static and dynamic facial wrinkles, restore facial contours, and deliver reconstructive skin-boosting effects through a unique combination of Hyaluronic Acid and Peptide Complex technology.
GLOBAL PARTNERSHIP
Akumentis Healthcare × Caregen
Akumentis Healthcare brings the globally trusted aesthetic innovation of Caregen to India, introducing advanced peptide-based dermal solutions designed for modern dermatology and aesthetic medicine.
Through this strategic collaboration, Akumentis delivers Caregen’s cutting-edge biotechnology, including the revolutionary CG Dimono PTx Dynamic Functional Dermal Filler, combining Hyaluronic Acid and peptide complex technology to restore facial contours, treat wrinkles, and support regenerative skin improvement.
Together, Akumentis and Caregen aim to provide healthcare professionals with innovative, scientifically developed aesthetic solutions that ensure safety, effectiveness, and natural-looking results.
PRODUCT OVERVIEW
What Is CG Dimono PTx?
CG DimonoPTX is injected into the mid-to-deep dermal layer at the site of cutaneous depression for the treatment of subcutaneous tissue damage caused by chemical, physical, and traumatic effects — including facial wrinkles, folds, nasolabial folds — and to restore the shape of the face.
Its formulation combines three key active components: PBS (Phosphate Buffered Saline), Sodium Hyaluronate (1.0%), and a Peptide Complex (Sh-Pentapeptide-12 SP, Octapeptide-11). This unique blend delivers reconstructive filling, relaxing, and skin-boosting effects simultaneously. Available in 1ml and 2ml formats, CG DimonoPTX is designed for high adaptability with no pumping or swelling.
1ml / 2ml
Available volumes
Mid-Deep
Dermal injection layer
HA + Peptide
Active complex
KEY FEATURES
Why CG Dimono PTx Stands Apart
Specific & Selective Action
The functional and dynamic characteristics of CG DimonoPTX make it specific and selective for treating facial wrinkles that are both static and dynamic in nature — a dual capability rarely found in a single filler.
Reconstructive & Boosting
The combination of HA and Peptide Complex delivers reconstructive filling, relaxing, and skin-boosting effects simultaneously, addressing multiple skin concerns in a single treatment session.
High Adaptability
CG DimonoPTX offers high adaptability with no pumping or swelling, ensuring natural-looking results that integrate seamlessly with the patient’s existing facial structure and movement.
Efficient Treatment Protocol
Recommended at 1 session every 2–3 months (4–5 sessions per year), using a linear intra-dermal injection technique for consistent, long-lasting results with minimal patient downtime.
APPLICATIONS
Treatment Areas*
CG DimonoPTX addresses a comprehensive range of facial and body areas, from fine crow’s feet and vertical forehead lines to nasolabial folds, perioral wrinkles, barcode lips, neck bands, and hand rejuvenation — making it one of the most versatile dermal fillers available.
Forehead*
Vertical & horizontal wrinkles — 1–2ml
Periorbital*
Crow’s feet, tear troughs, circles — 0.5–1ml
Nasolabial*
Nasolabial folds — 0.5–2ml
Perioral*
Barcode lip, perioral lines — 0.5–1ml
Neck & Chest*
Horizontal neck bands — 0.5–2ml
Hands*
Dorsal hand rejuvenation — variable
CLINICAL RESULTS **
Face — Wrinkles & Skin Boosting
Clinical test results demonstrate significant improvement in both static and dynamic wrinkles across multiple patient profiles. Before-and-after photography from side and front views confirms visible reduction in forehead lines, cheek volume loss, and overall skin texture — with treatment volumes ranging from 0.5ml to 2ml per zone.
Side
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Front
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Static
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Dynamic
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Dynamic
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Dynamic
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Static
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Static
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CLINICAL RESULTS **
Forehead Wrinkles — Cases 1–4
Four documented cases demonstrate CG DimonoPTX’s effectiveness on both dynamic and static forehead wrinkles. Results show marked smoothing of horizontal lines at rest and during facial expression, confirming the product’s dual static-dynamic efficacy.
Case 1 — Dynamic
Dynamic
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Case 2 — Dynamic
Dynamic
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Case 3 — Static & Dynamic
Static
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Case 4 — Dynamic
Dynamic
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CLINICAL RESULTS **
Peri-Oral, Lips & Barcode Lips
CG DimonoPTX addresses both static and dynamic wrinkles around the mouth, including barcode lip lines, while supporting overall lip volume. Clinical cases show fuller, smoother lips and significantly reduced perioral lines in both static and dynamic states.
Static
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Dynamic
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Dynamic
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Lip Cases 1 & 2 — Dynamic
Dynamic
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Dynamic
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Lip Cases 3 & 4 — Static
Static
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Static
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CLINICAL RESULTS **
Neck — Case 1 (Static, 1.5 Months)
Static
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After (1.5 Months)
Visible reduction in horizontal neck bands after just one and a half months of treatment.
Hands — Before & Immediately After
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Hand rejuvenation results shown immediately post-treatment, at 10 days, 2 weeks, and 2 months — demonstrating progressive and lasting improvement.
KEY FEATURES
Three Pillars of CG-PTx Technology*
CG-PTx’s superiority rests on three scientifically validated pillars that work in concert to deliver botulinum toxin-like results without injection. Each pillar represents a breakthrough in peptide science and delivery technology.
1
Superiority of PTx Peptide
CG-PTx is a Botulinum Toxin Type C-like peptide, enzymatically cleaving Syntaxin-1a and SNAP-25 in nerve cells — the same mechanism as botulinum toxin, but delivered safely as a peptide.
2
Transdermal Delivery System
An exclusive transdermal delivery system enables CG-PTx to penetrate through the epidermis and dermis all the way to the muscle layer — confirmed by fluorescence microscopy showing the peptide reaching nerve cells in the muscle.
3
Cell Membrane Penetration
Once delivered transdermally, CG-PTx penetrates directly into the cytosol and nucleus of neuronal cells, enabling direct action on the SNARE complex proteins responsible for muscle contraction and wrinkle formation.
ACTION MECHANISM *
How PTx Relaxes Muscles
PTx acts like Botulinum Toxin type C, cleaving Syntaxin and SNAP-25 in nerve cells. Under normal conditions, SNARE proteins (Syntaxin, SNAP-25, Synaptobrevin) facilitate the release of acetylcholine from synaptic vesicles into the neuromuscular junction, triggering muscle contraction. CG-PTx disrupts this process by breaking down the SNARE complex, preventing acetylcholine release and resulting in muscle relaxation — and therefore wrinkle reduction.
Normal Neurotransmitter Release
Acetylcholine released via intact SNARE complex → muscle contraction → wrinkle formation.
Muscle Relaxation via CG-PTx
CG-PTx cleaves Syntaxin & SNAP-25 → SNARE complex breakdown → no acetylcholine release → muscle relaxation.
SCIENTIFIC EVIDENCE *
Superiority of PTx Peptide
1 Cleavage Test on Syntaxin 1a & SNAP-25
Three independent laboratory tests confirm CG-PTx’s enzymatic activity on key SNARE proteins. In human bone marrow neuroblastoma cells (SH-sy5y), western blot analysis demonstrated dose-dependent cleavage of both Syntaxin 1a and SNAP-25 at concentrations of 10nM, 50nM, and 100nM over 4 hours. A cell-free system test further confirmed cleavage of recombinant Syntaxin 1a. Immunocytochemistry at 100nM showed a significant reduction in the Syntaxin 1a green signal compared to control, visually confirming protein cleavage within neuronal cells.
(a) Western Blot — Nerve Cells
CG-PTx enzymatically cleaved Syntaxin-1a and SNAP-25 in nerve cells.
(b) Western Blot — Cell-Free System
CG-PTx enzymatically cleaved Syntaxin 1a in cell-free system.
(c) Immunocytochemistry — Syntaxin 1a Localization at 100nM
Syntaxin la
Green: Syntaxinla, SNAP-25
Blue: Nucleus
Green: Syntaxinla, SNAP-25
Blue: Nucleus
Control
CG-PTx
Control ×40
CG-PTx ×40
Green: Syntaxin1a / SNAP-25 · Blue: Nucleus. Significant reduction in Syntaxin 1a signal confirms effective cleavage at 100nM.
2 Inhibition of SNARE Complex
Cell: Human Bone Marrow Neuroblastoma (SH-sy5y). Treatment condition: Treat 24hr in serum-free DMEM. Peptide concentration: 10, 50, 100uM / BoNT/A 0.05, 0.5U. Analysis: Western blot.
3 Inhibition of Acetylcholine Release
Cell: Human Bone Marrow Neuroblastoma (SH-sy5y). Culture condition: Serum free DMEM for 48hrs. Induction: NIC(Nicotine)+KCl(Potassium chloride) 30min. Analysis: Choline/Acetylcholine assay kit.
Transdermal Delivery *
Delivery to the Muscle Layer — Confirmed by Histology
One of the most remarkable aspects of CG-PTx is its ability to penetrate through all skin layers — epidermis, dermis, and down to the muscle — without injection. Histological analysis using H&E staining and fluorescence microscopy confirms that the rhodamine-labeled PTx peptide (shown in red) successfully reaches the muscle layer and co-localizes with TrkB-labeled nerve cells (shown in green). This transdermal delivery capability is the foundation of PTx’s needle-free efficacy, enabling it to act directly at the neuromuscular junction where wrinkle-causing muscle contractions originate.
H&E staining
Blue: DAPI-Nucleus
Green: TrkB — Nerve cell
Red: Rhodamine-PTx Peptide
Merge
CELL MEMBRANE PENETRATION *
PTx Penetration Into Neuronal Cells
Confocal fluorescence microscopy at x400 and x1400 magnification confirms that CG-PTx penetrates into both the cytosol and nucleus of neuronal cells. Using human bone marrow neuroblastoma cells (SH-sy5y) treated for 1 hour in serum-free DMEM, the rhodamine-labeled CG-PTx (red) is clearly visible inside the cells, merging with the DAPI nuclear stain (blue) to produce a pink signal — confirming intracellular delivery.
This direct intracellular penetration is what enables CG-PTx to reach and cleave the SNARE complex proteins within the nerve cell, producing its muscle-relaxing and anti-wrinkle effects.
Blue: DAPI
Nucleus marker
Red: Rhodamine
CG-PTx peptide
Pink: Merge
Intracellular co-localization
Why Akumentis Healthcare
Akumentis Healthcare is committed to bringing the most innovative and scientifically validated aesthetic solutions to medical professionals. Our partnership approach ensures that practitioners have access to cutting-edge technologies backed by comprehensive clinical support, educational resources, and ongoing training. CG Dimono PTx represents our dedication to advancing the field of aesthetic medicine through evidence-based innovation that delivers superior patient outcomes and enhanced practice differentiation.
Quality Assurance
Every product meets rigorous quality standards with comprehensive testing protocols ensuring consistency, safety, and efficacy across all batches.
Clinical Support
Dedicated technical support team provides injection technique guidance, treatment planning assistance, and case consultation services.
Professional Education
Comprehensive training programs, educational materials, and hands-on workshops ensure optimal treatment outcomes and practitioner confidence.
Ready to Transform Your Practice?
Contact Akumentis Healthcare today to learn more about incorporating CG Dimono PTx into your aesthetic treatment menu. Our team is ready to provide detailed product information, clinical support, and practice integration guidance to help you deliver exceptional results to your patients.
CG Dimono PTx is a medical device intended for use by licensed medical professionals trained in aesthetic injection techniques. Individual results may vary based on patient characteristics, injection technique, and treatment parameters. Practitioners should review complete product information and conduct thorough patient consultations prior to treatment.
*Data on file, as shared by Caregen team, and **Clinical studies done by Caregen
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